Maribavir (Livtencity)
نویسندگان
چکیده

 CADTH recommends that Livtencity should be reimbursed by public drug plans for the treatment of adults with post-transplant cytomegalovirus (CMV) infection/disease who are refractory (with or without genotypic resistance) to 1 more prior antiviral therapies if certain conditions met.
 only covered treat adult patients CMV infections following drugs: valganciclovir, ganciclovir, foscarnet, cidofovir.
 prescribed clinicians experience and expertise in transplant medicine, infectious disease, diseases, cost is reduced.
منابع مشابه
Cytomegalovirus UL97 kinase mutations that confer maribavir resistance.
The cytomegalovirus (CMV) UL97 kinase inhibitor maribavir (MBV) is undergoing clinical antiviral trials. Two clinical CMV isolates serially passaged in cell culture under MBV showed >20-fold increases in MBV resistance after the development of the UL97 mutation V353A in one of the isolates and of T409M in the other. Marker transfer studies confirmed that the V353A and T409M mutations conferred ...
متن کاملEffect of ketoconazole on the pharmacokinetics of maribavir in healthy adults.
Maribavir, an oral antiviral drug with activity against cytomegalovirus, is currently undergoing studies to assess its efficacy and safety as cytomegalovirus prophylaxis following stem cell or solid organ transplantation. The main objective of this study was to assess the effects of oral ketoconazole, a potent inhibitor of the cytochrome P450 3A4 (CYP3A4) isoenzyme, on the pharmacokinetics of m...
متن کاملDifferential properties of cytomegalovirus pUL97 kinase isoforms affect viral replication and maribavir susceptibility.
UNLABELLED The human cytomegalovirus (HCMV)-encoded kinase pUL97 is required for efficient viral replication. Previous studies described two isoforms of pUL97, the full-length isoform (M1) and a smaller isoform likely resulting from translation initiation at codon 74 (M74). Here, we report the detection of a third pUL97 isoform during viral infection resulting from translation initiation at cod...
متن کاملMaribavir inhibits epstein-barr virus transcription in addition to viral DNA replication.
Although many drugs inhibit the replication of Epstein-Barr virus (EBV) in cell culture systems, there is still no drug that is effective and approved for use in primary EBV infection. More recently, maribavir (MBV), an l-ribofuranoside benzimidazole, has been shown to be a potent and nontoxic inhibitor of EBV replication and to have a mode of action quite distinct from that of acyclic nucleosi...
متن کاملMaribavir inhibits Epstein-Barr virus transcription through the EBV protein kinase.
Maribavir (MBV) inhibits Epstein-Barr virus (EBV) replication and the enzymatic activity of the viral protein kinase BGLF4. MBV also inhibits expression of multiple EBV transcripts during EBV lytic infection. Here we demonstrate, with the use of a BGLF4 knockout virus, that effects of MBV on transcription take place primarily through inhibition of BGLF4. MBV inhibits viral genome copy numbers a...
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ژورنال
عنوان ژورنال: Canadian journal of health technologies
سال: 2022
ISSN: ['2563-6596']
DOI: https://doi.org/10.51731/cjht.2022.504